【佳学基因检测】临床心理学的进化和遗传见解

千万不要做基因检测合理吗

挖掘精神科基因组学个性化药物选择记录《Clin Psychol Rev》在. 2020 Jun;78:101857.发表了一篇题目为《临床心理学的进化和遗传见解》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Bernard J Crespi等完成。促进了肿瘤的精准治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

神经疾病遗传阻断及精准治疗临床研究内容关键词：

精神科心理科疾病用药指导基因检测临床应用结果

遗传学的最新进展以及进化生物学的新应用正在改变心理学和精神病学。本文的目的是回顾和综合这两个对临床心理学实践最为突出的领域的进展。首先，我描述了全基因组研究的结果如何阐明精神疾病的遗传结构。这些遗传结果可用于生成多基因风险评分，识别罕见的因果突变，评估基因与环境的相互作用，并帮助确定每个人精神疾病的具体原因，所有这些都有助于指导治疗和治疗。其次，我解释了应用于人类发展、人类心理和精神障碍的进化理论如何导致与治疗相关的新见解。精神病学和心理学的进化思维与临床心理学的当代学派一致，但也提供了新颖、非直觉和临床有用的见解。基因组对发育的影响，以及成人心理的功能，都被认为是动态的、非线性的系统，受反馈的调节，可以以可预测但个人主义的方式变得无序。遗传、神经学、心理学和进化方法的融合将改变临床心理学和精神病学，但需要更加重视跨学科思维和研究。动力系统；进化生物学；健康;基因组学。

神经及精神疾病及其并发征、合并征国际数据库描述：

Recent advances in genetics, and new applications of evolutionary biology, are transforming psychology and psychiatry. The purpose of this article is to review and synthesize the progress in these two areas that is most salient to the practice of clinical psychology. First, I describe how the results of genome-wide studies have elucidated the genetic architectures of psychiatric disorders. These genetic results can be applied to generate polygenic risk scores, identify rare causal mutations, evaluate gene by environment interactions, and help determine the specific causes of psychiatric disorders for each individual, all of which can help to guide therapies and treatments. Second, I explain how evolutionary theory, applied to human development, the human psyche, and mental disorders, leads to novel insights relevant to therapy. Evolutionary thinking for psychiatry and psychology is consilient with contemporary schools of thought in clinical psychology, but also provides novel, non-intuitive, and clinically-useful insights. Effects of the genome in development, and functioning of the adult psyche, are both usefully conceived as dynamical, non-linear systems, regulated by feedbacks, that can become disordered in predictable yet individualistic ways. The merging of genetic, neurological, psychological, and evolutionary approaches is set to transform clinical psychology and psychiatry, but requires increased emphasis on cross-disciplinary thinking and research.Keywords: Adaptation; Dynamical systems; Evolutionary biology; Fitness; Genomics.