【佳学基因检测】密码子 72 的 P53 多态性与泰国人群中的角化囊性牙源性肿瘤有关
肿瘤基因检测龙头企业检测项目
在高峰论坛中博士医师年度双基练习体会到《Asian Pac J Cancer Prev》在. 2015;16(5):1997-2001.发表了一篇题目为《密码子 72 的 P53 多态性与泰国人群中的角化囊性牙源性肿瘤有关》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Pattamawadee Yanatatsaneejit , Ajaree Boonsrang, Apiwat Mutirangura, Vyomesh Patel, Nakarin Kitkumthorn等完成。促进了肿瘤的精准治疗与个性化用药的发展,进一步强调了基因信息检测与分析的重要性。
癌症个性化药物选择临床研究内容关键词:
p53密码子,多态性,关联性分析,角囊性,牙源性肿瘤
肿瘤靶向治疗基因检测临床应用结果
目的:阐明 p53 密码子 72 多态性与散发性角囊性牙源性肿瘤 (KCOT) 易感性之间的关联。设计:对 100 名 KCOT 和 160 名匹配组健康对照进行基因分型,以确定 p53 密码子 72 多态性的频率。聚合酶链反应-限制性片段长度多态性(PCR-RFLP),通过直接测序证实。结果:Pro/Pro、Arg/Pro和Arg/Arg基因型的频率分别为23.8%、49.4%和26.9% ,在对照组中,而 KCOT 队列分别表现出 43.0%、39.0% 和 18.0%。进一步分析表明,p53 Pro 可能是 KCOT 易感等位基因(OR (95%CI)=1.77 (1.22 to 2.59), p=0.0024),性别调整的 OR (95%CI) 为 1.71 (1.17-2.50) ),p = 0.0046。此外,结果表明 p53 密码子 72 Pro 纯合子与发生 KCOT 的两倍风险相关(调整后的 OR (95%CI) =2.17(1.23-3.84),p=0.0062)。结论:C/C 基因型P53 基因密码子 72 增加了发生散发性 KCOT 的风险,并且可能是用于筛查和诊断目的的有用工具。
肿瘤发生与复发转移国际数据库描述:
Objective: To clarify the association between the p53 polymorphism at codon 72 and susceptibility to the sporadic keratocystic odontogenic tumor (KCOT).Design: One hundred KCOTs and 160 match-group healthy controls were genotyped to ascertain the frequency of the p53 codon 72 polymorphism using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), confirmed by direct sequencing.Results: The frequencies of the Pro/Pro, Arg/Pro, and Arg/Arg genotypes were 23.8%, 49.4%, and 26.9%, respectively, in the controls, while the KCOT cohort demonstrated 43.0%, 39.0%, and 18.0%, respectively. Further analysis suggested that p53 Pro could be a KCOT-susceptible allele (OR (95%CI)=1.77 (1.22 to 2.59), p=0.0024), with a sex-adjusted OR (95%CI) of 1.71 (1.17-2.50), p=0.0046. Moreover, the results indicated that p53 codon 72 Pro homozygous was associated with a two-fold risk of developing KCOT (adjusted OR (95%CI) =2.17(1.23-3.84), p=0.0062).Conclusions: The C/C genotype of P53 gene codon 72 increases the risk of developing sporadic KCOT and may be a useful tool for screening and diagnostic purposes.
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(责任编辑:佳学基因)