【佳学基因检测】多囊卵巢综合征相关肿瘤坏死因子-α启动子-1031(T/C)多态性

基因检测大约多少钱比较分析

数据分析肿瘤基因学知识要点获悉《Reprod Biol Endocrinol》在. 2011 Oct 4;9:131.发表了一篇题目为《多囊卵巢综合征相关肿瘤坏死因子-α启动子-1031(T/C)多态性》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Ji-Hyun Yun, Jin-Woo Choi, Kyung-Ju Lee, Joong-Sik Shin, Kwang-Hyun Baek等完成。促进了肿瘤的精准治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

肿瘤靶向药物及精准治疗临床研究内容关键词：

动脉瘤性骨囊肿,荧光原位杂交,骨巨细胞瘤, USP6 基因

肿瘤靶向治疗基因检测临床应用结果

基因解码基因检测的研究介绍：肿瘤坏死因子-α是一种多功能促炎细胞因子，已被认为是多种疾病的致病因子之一。据报道，肿瘤坏死因子-α基因中的启动子-1031(T/C)多态性在生殖相关疾病中起作用。其中，已知多囊卵巢综合征（PCOS）是育龄妇女常见的妇科疾病。在此，基因解码基因检测在韩国人群中进行了TNF-α基因-1031(T/C)多态性与PCOS的比较研究。基因解码基因检测的研究方法：通过聚合酶链反应分析TNF-α基因的-1031(T/C)多态性。总共 217 名 PCOS 患者和 144 名健康女性的匹配女性对照中的限制性片段长度多态性 (PCR-RFLP)。并使用HapAnalyzer进行统计分析。采用X2检验和逻辑回归分析两组之间的关联。 p值低于0.05被认为具有统计学意义。基因解码基因检测的研究结果：基因型和等位基因频率处于Hardy-Weinberg平衡（HWE）。 TNF-α基因启动子区的-1031(T/C)多态性与PCOS有很强的相关性（p值= 0.0003，奇数比（OR）= 2.53）。此外，与对照组相比，PCOS 患者中 C 等位基因的频率显着更高。序列分析还显示TNF-α基因-1031(T/C)多态性。基因解码基因检测的研究结论：这是对PCOS中TNF-α基因-1031(T/C)多态性的首次研究。基因解码基因检测得出基因解码基因检测的研究结论，TNF-α 基因的-1031(T/C) 多态性与韩国人群中的PCOS 相关。因此，有可能将其作为诊断PCOS的临床生物标志物，有助于了解PCOS的发病机制。

肿瘤发生与复发转移国际数据库描述：

Background: A tumor necrosis factor-alpha is a multifunctional pro-inflammation cytokine, which has been considered as one of pathogenic factors for various diseases. The promoter -1031(T/C) polymorphism in the tumor necrosis factor-alpha gene was reported that it plays a part in reproduction-related diseases. Among these, polycystic ovary syndrome (PCOS) is known to be a common gynecological disease of women in reproductive age women. Here, we performed a comparative study of -1031(T/C) polymorphism of TNF-alpha gene with PCOS in a Korean population.Methods: The -1031(T/C) polymorphism of TNF-alpha gene was analyzed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) in a total of 217 PCOS patients and 144 matched female controls of healthy women. And statistical analysis was performed using HapAnalyzer. X2 test and logistic regression were utilized analyze the association between two groups. A p-value under 0.05 was considered statistically significant.Results: The genotype and allelic frequencies were in Hardy-Weinberg equilibrium (HWE). There was strong association between the -1031(T/C) polymorphism in the promoter region of TNF-alpha gene and PCOS (p-value = 0.0003, odd ratio (OR) = 2.53). In addition, the frequency of C allele was significantly higher in PCOS patients compared with controls. Sequence analyses also showed the -1031(T/C) polymorphism of TNF-alpha gene.Conclusion: This is the first study on the -1031(T/C) polymorphism of TNF-alpha gene in PCOS. We concluded that the -1031(T/C) polymorphism of TNF-alpha gene is associated with PCOS in a Korean population. Therefore, it is possible that it may be considered as a clinical biomarker to diagnose for PCOS, and is helpful in understanding the etiology for the pathogenesis of PCOS.