【佳学基因检测】使用类器官技术对自闭症进行建模

神经病基因检测多少钱一次—目标

小组讨化精神科基因学知识要点《精神与神经疾病致病基因突变位点的性质及影响分析》《Mol Neurobiol》在. 2017 Dec;54(10):7789-7795.发表了一篇题目为《使用类器官技术对自闭症进行建模》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Hwan Choi, Juhyun Song, Guiyeon Park, Jongpil Kim等完成。促进了肿瘤的精准治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

神经疾病遗传阻断及精准治疗临床研究内容关键词：

腺相关病毒载体，AAV,睫状神经营养因子，CDNF,封装细胞,基因治疗,胶质源性神经营养因子，GDNF,神经营养因子,神经营养因子

精神科心理科疾病用药指导基因检测临床应用结果

自闭症是一种由发育过程中的多种突变引起的神经发育疾病。然而，尚无合适的疾病模型来研究疾病发作和进展的分子途径。尽管许多研究使用人类干细胞如诱导多能干细胞和胚胎干细胞来研究疾病的发病机制，但这些干细胞技术在研究自闭症等神经发育疾病的病理学和发病机制方面的能力有限。因此，研究人员正专注于模拟器官、类器官的三维 (3D) 结构的优势，以模拟自闭症。在这篇综述中，我们强调了 3D 类器官系统在研究自闭症发病机制方面的优势。此外，由于自闭症的发病是由遗传背景决定的，我们建议应用成簇的规则散布短回文重复相关蛋白 9 (CRISPR/Cas9) 技术在 3D 类器官系统中进行基因组编辑，以研究导致自闭症的突变。我们提出结合 CRISPR/Cas9 技术的 3D 类器官系统可能会推进自闭症研究。成簇的规则散布的短回文重复相关蛋白 9 (CRISPR/Cas9)；诱导多能干细胞（iPSC）；类器官。

神经及精神疾病及其并发征、合并征国际数据库描述：

Autism is a neurodevelopmental disease caused by multiple mutations during development. However, a suitable disease model to study the molecular pathway of disease onset and progression is not available. Although many studies have used human stem cells such as induced pluripotent stem cells and embryonic stem cells to investigate the disease pathogenesis, these stem cell techniques are limited in their abilities to study the pathology and mechanism of pathogenesis of neurodevelopmental diseases such as autism. Therefore, researchers are focusing on the strengths of three-dimensional (3D) structures mimicking organs, organoids, for modeling autism. In this review, we highlight the advantages of 3D organoid systems to investigate the mechanisms of the pathogenesis of autism. Further, because the onset of autism is determined by genetic background, we suggest the application of the clustered regularly interspersed short palindromic repeat-associated protein 9 (CRISPR/Cas9) technique for genome editing in 3D organoid systems to study mutations that cause autism. We propose that 3D organoid systems combined with the CRISPR/Cas9 technique may advance autism research.Keywords: Autism; Clustered regularly interspersed short palindromic repeat-associated protein 9 (CRISPR/Cas9); Induced pluripotent stem cells (iPSCs); Organoids.