【佳学基因检测】人格障碍的行为遗传学：为 DSM-5 中的分类和概念化提供信息

神经内科基因检测费17800说明

开会学习医学博士年度神经科疾病汇报《精神与神经疾病基因易感位点列表及发生率分析》《Personal Disord》在. 2013 Jul;4(3):270-83.发表了一篇题目为《人格障碍的行为遗传学：为 DSM-5 中的分类和概念化提供信息》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Susan C South, Nathaniel J DeYoung等完成。促进了肿瘤的精准治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

神经疾病遗传阻断及精准治疗临床研究内容关键词：

天使综合征,脆性X综合征,基因治疗,神经发育障碍,雷特综合征,SLC13A5,SLC6A1

精神科心理科疾病用药指导基因检测临床应用结果

人格病理学目前在诊断和统计手册中通过 10 个分类人格障碍 (PD) 诊断被分为三个描述性集群。该分类系统因在做出临床决策时使用离散类别和任意阈值而受到许多人的批评。为了解决这些批评，DSM-5 人格和人格障碍工作组提出了一项提案，该提案显着改变了 DSM-IV PD 部分的结构和内容。如果这个 DSM-5 工作组对实证文献进行了自己的系统审查，那么该审查尚未发布或广泛提供。因此，由整个心理学界来确定建议的变化与现有 PD 研究结果的一致性程度。目前的文章通过解决行为遗传学发现对 DSM-5 中 PD 分类修订过程的贡献来加入这项工作。首先，我们简要回顾了 DSM 中 PD 分类的历史。接下来，我们对 PD 诊断的五个主要建议变化中的每一个进行概述和基本原理。对于每个建议的变化，我们概述了来自行为遗传学的可用证据以及对这些发现的解释。最后，我们总结了随着 DSM-5 向前发展对 PD 分类的考虑。对行为遗传学文献的回顾表明，DSM-5 提案的几个特征，包括消除 4 个 PD、将临床疾病和 PD 合并在一个轴上以及实施特征评级系统，需要在产品之前进行更多的解释最终确定。

神经及精神疾病及其并发征、合并征国际数据库描述：

Personality pathology is currently captured in the Diagnostic and Statistical Manual through 10 categorical personality disorder (PD) diagnoses grouped into three descriptive clusters. This classification system has been criticized by many for using discrete categories and arbitrary thresholds when making clinical decisions. To address these critiques, the DSM-5 Personality and Personality Disorders Work Group has put forth a proposal that significantly alters the structure and content of the DSM-IV PD section. If this DSM-5 Work Group has conducted its own systematic review of the empirical literature, this review has not been released or made widely available. As such, it is up to the psychology community at large to determine how well the suggested changes align with findings from extant PD research. The current article joins this effort by addressing the contribution of behavior genetic findings to the revision process for classification of PDs in DSM-5. First, we provide a brief review of the history of PD classification in the DSM. Next, we present an overview and rationale for each of the five major suggested changes to PD diagnoses. For each suggested change, we outline the available evidence from behavior genetics and interpretations of these findings. Finally, we offer a summary of considerations for PD classification as the DSM-5 moves forward. Review of the behavior genetics literature suggests that several features of the DSM-5 proposal, including the elimination of 4 PDs, merging clinical disorders and PDs on a single axis, and the implementation of a trait rating system, require significantly greater explication before a product is finalized.