【佳学基因检测】遗传学和基因组学在临床精神病学中的作用

精神病基因检测哪家医院最好解析

阅读精神病的精准化治疗及靶向药物选择发现《Dialogues Clin Neurosci》在. 2018 Sep;20(3):169-177.发表了一篇题目为《遗传学和基因组学在临床精神病学中的作用》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Margret R Hoehe, Deborah J Morris-Rosendahl等完成。促进了肿瘤的精准治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

遗传力、发病原因及精准治疗临床研究内容关键词：

神经科用药指导基因检测临床应用结果

许多疾病的遗传学和基因组学取得的巨大成功为精准医学的进步奠定了基础。因此，与神经精神疾病以及治疗结果相关的基因变异的检测已经引起了人们越来越多的期望，即这些发现可以很快转化为临床，以改善诊断、疾病风险的预测和个体对药物治疗的反应。在本文中，我们将介绍寻找与精神疾病有关的基因，并总结目前在主要精神疾病中的发现。我们将回顾编码药物代谢酶和特定药物靶标的基因中的遗传变异，这些变异被发现与可变的药物反应和严重的副作用有关。我们将评估这些发现的临床可翻译性，目前是否有基因检测的任何作用，并在这种情况下，为临床医生提供有价值的信息来源，以便在这个快速发展的精神遗传学领域寻求指导和建议。关键词：基因检测;遗传学；基因组学；药物基因组学；精神障碍。

神经及精神疾病及其并发征、合并征国际数据库描述：

The enormous successes in the genetics and genomics of many diseases have provided the basis for the advancement of precision medicine. Thus, the detection of genetic variants associated with neuropsychiatric disorders, as well as treatment outcome, has raised growing expectations that these findings could soon be translated into the clinic to improve diagnosis, the prediction of disease risk and individual response to drug therapy. In this article, we will provide an introduction to the search for genes involved in psychiatric illness and summarize the present findings in major psychiatric disorders. We will review the genetic variants in genes encoding drug metabolizing enzymes and specific drug targets which were found to be associated with variable drug response and severe side effects. We will evaluate the clinical translatability of these findings, whether there is currently any role for genetic testing and in this context, make valuable sources of information available to the clinician seeking guidance and advice in this rapidly developing field of psychiatric genetics.Keywords: genetic testing; genetics; genomics; pharmacogenomics; psychiatric disorder.